Sublocade Shot (How It Works, Side Effects, + More)

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Sublocade is a type of Medication-Assisted Treatment and prescription medication used to treat opioid use disorder (OUD). 

For individuals struggling with opioid addiction, Sublocade can be a key component of a comprehensive treatment plan. At Peachtree Detox, we offer comprehensive detox programs in Atlanta that include the use of Sublocade, if clinically appropriate.

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What is Sublocade & How Does The Sublocade Shot Work?

Sublocade is a form of buprenorphine administered as a once-monthly shot. 

Buprenorphine is a partial opioid agonist, which means it binds to opioid receptors in the brain, reducing cravings and withdrawal symptoms without producing the same high as full opioids. Sublocade is injected subcutaneously (under the skin) and is slowly released over 30 days, providing continuous medication to help stabilize individuals in recovery.

This extended-release mechanism ensures that patients receive a consistent dose of buprenorphine throughout the month, reducing the need for daily medication.

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What Is The Sublocade Shot Used For?

Sublocade is primarily used to treat moderate to severe opioid use disorder and those undergoing opioid detox. It is often prescribed as part of a Medication-Assisted Treatment (MAT) program, which combines medications with counseling and behavioral therapies. MAT has been shown to improve recovery outcomes, reduce the risk of relapse, and help individuals achieve long-term sobriety.

Sublocade is usually prescribed to individuals who have already started treatment with buprenorphine and have stabilized on a daily dose of an oral version, such as Suboxone. Once stabilized, Sublocade helps maintain this balance by delivering a consistent dose each month.

Potential Side Effects of Sublocade

Sublocade is effective in treating opioid addiction. However, it can cause side effects, some of which may be serious. 

Common side effects include:

  • Nausea or vomiting
  • Headache
  • Fatigue or tiredness
  • Constipation
  • Insomnia or trouble sleeping
  • Sweating

In more rare cases, Sublocade can lead to more severe side effects, such as:

  • Injection site reactions (pain, itching, redness)
  • Liver issues (jaundice, dark urine)
  • Respiratory issues (trouble breathing)
  • Allergic reactions (hives, swelling)

If you experience any severe side effects or symptoms of an allergic reaction, it’s important to seek medical attention immediately.

Sublocade vs Vivitrol

Both Sublocade and Vivitrol are injectable medications used in treating opioid use disorder, but they function differently. 

Sublocade contains buprenorphine, a partial opioid agonist, while Vivitrol contains naltrexone, an opioid antagonist.

  • Sublocade: Helps reduce cravings and withdrawal symptoms by partially activating opioid receptors.
  • Vivitrol: Blocks opioid receptors entirely, preventing the effects of opioids if used.


Sublocade is generally more suited for individuals who are still experiencing cravings or withdrawal symptoms, whereas Vivitrol is often used after detoxification when a person has completely stopped using opioids.

Sublocade vs Suboxone

Suboxone and Sublocade both contain buprenorphine, but they differ in their administration and duration of action.

  • Suboxone: Comes in an oral form, typically taken daily, and contains both buprenorphine and naloxone to deter misuse.
  • Sublocade: Is a monthly injection of buprenorphine without naloxone, offering a long-lasting, consistent release of medication.

Sublocade can be more convenient for individuals who struggle with adhering to daily medication schedules or are at risk of misuse. Suboxone, on the other hand, offers more flexibility for those who prefer daily control over their medication intake.

How Long Does Sublocade Stay In Your System?

After the first injection, Sublocade stays in the body for approximately 30 days, gradually releasing buprenorphine into the bloodstream. The effects of the shot are long-lasting, and the medication may remain detectable in your system for up to a month or longer, depending on factors like metabolism, dosage, and overall health.

Understanding Sublocade’s Extended-Release Mechanism

Sublocade is designed as a depot injection that forms a solid mass under the skin after administration. This solid depot slowly dissolves over time, providing a continuous release of buprenorphine for approximately one month. This extended-release system ensures consistent medication levels in your bloodstream without the need for daily dosing.

Detection Timeframes by Testing Method

The length of time Sublocade remains detectable varies depending on the type of test used:

  • Blood tests: Buprenorphine can typically be detected for 2-7 days after the last injection
  • Urine tests: May detect buprenorphine for up to 30 days or longer
  • Hair tests: Can potentially detect the medication for up to 90 days
  • Saliva tests: Generally detectable for 1-3 days

Factors Affecting How Long Sublocade Stays in Your System

Several individual factors influence how quickly your body processes and eliminates Sublocade:

  • Metabolism rate: People with faster metabolisms may eliminate the medication more quickly
  • Body composition: Factors like weight, muscle mass, and body fat percentage can affect drug clearance
  • Liver function: Since buprenorphine is primarily metabolized by the liver, liver health impacts elimination
  • Kidney function: The kidneys play a role in eliminating medication metabolites
  • Age: Older adults may process medications more slowly
  • Dosage strength: Higher doses (300mg vs 100mg) may remain detectable longer
  • Duration of treatment: Long-term use can lead to accumulation in body tissues
  • Hydration levels and overall health status

Sublocade For Alcohol

Sublocade is specifically FDA-approved for the treatment of opioid use disorder and is not indicated for alcohol addiction. The medication contains buprenorphine, an opioid partial agonist that works by binding to the same brain receptors affected by opioids like heroin, fentanyl, and prescription painkillers.

Why Sublocade Isn’t Used for Alcohol Addiction

Alcohol use disorder involves different brain pathways and neurotransmitter systems than opioid addiction. Buprenorphine, the active ingredient in Sublocade, does not effectively address the brain changes caused by chronic alcohol use. Using Sublocade for alcohol addiction alone would not provide the targeted treatment needed for recovery.

Dual Diagnosis Considerations

Some individuals may struggle with both opioid and alcohol use disorders simultaneously. In these cases, Sublocade may be prescribed as part of a comprehensive treatment plan that addresses the opioid addiction while separate interventions target alcohol use. This requires careful medical supervision and coordination between treatment providers.

If you’re seeking treatment for alcohol addiction, it’s important to work with healthcare providers who specialize in addiction medicine to determine the most appropriate treatment approach for your specific situation.

What Is The Success Rate of Sublocade?

Sublocade has been shown to be highly effective in supporting long-term recovery from opioid addiction.

Clinical studies indicate that individuals treated with Sublocade experienced significantly reduced cravings and opioid use, with many achieving sustained sobriety.

As with any treatment, success rates improve when combined with comprehensive care, including counseling and other behavioral therapies.

How Long Do I Stay On Sublocade?

The length of time a person stays on Sublocade varies depending on individual needs and treatment progress. 

Many individuals remain on Sublocade for several months to a year or longer, depending on how they respond to treatment. 

How Much Does Sublocade Cost?

The cost of Sublocade can vary significantly depending on your insurance coverage, location, and the treatment facility providing the injection.

Average Costs Without Insurance

Without insurance coverage, Sublocade can be expensive:

  • 100mg injection: Approximately $1,500-$1,800 per month
  • 300mg injection: Approximately $1,700-$2,000 per month

These costs typically include both the medication and the administration fee for the injection.

Insurance Coverage

Many insurance plans, including Medicaid and private insurance, may cover Sublocade when prescribed for opioid use disorder. Coverage varies by plan, and some may require:

  • Prior authorization from your doctor
  • Proof of previous treatment attempts
  • Step therapy requirements (trying other medications first)
  • Coverage for a specific number of injections per year

Begin Addiction Treatment in Atlanta, Georgia Today

If you or a loved one is struggling with opioid addiction, Sublocade could be an effective part of your recovery journey. At Peachtree Detox, we offer comprehensive treatment plans, including Medication-Assisted Treatment with Sublocade, to help you achieve lasting sobriety. 

Call us now at 470-613-7881 learn more about how our detox programs in Georgia can support your recovery.

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